This book constitutes the refereed proceedings of the 16th International Conference on Modeling Decisions for Artificial Intelligence, MDAI 2019, held in Milan, Italy, in September 2019. The 30 papers presented in this volume were carefully reviewed and selected from 50 submissions. They discuss different facets of decision processes in a broad sense and present research in data science, data privacy, aggregation functions, human decision making, graphs and social networks, and recommendation and search. The papers are organized in the following topical sections: aggregation operators and decision making; data science and data mining; and data privacy and security.  
