This book comprises carefully selected contributions derived from plenary and invited talks delivered during the International Conference on Mathematics of Intelligent Computing and Data Science (ICMICDS-22), held at the Rajagiri School of Engineering and Technology, Cochin, India, from 15 to 17 September 2022. The volume encompasses a diverse spectrum of subjects, including but not limited to artificial intelligence, machine learning, data analysis, and optimization. Acting as a valuable forum, this volume offers a pivotal platform for both researchers and practitioners to showcase their scholarly endeavors. It facilitates vibrant discussions on the latest advancements and serves as an avenue for the exploration of novel research trajectories within the realm of intelligent computing and data science.